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. 2014 Sep 16;5(12):1221–1237. doi: 10.1021/cn500153z

Figure 4.

Figure 4

Potency determinations of VU0422288 at mGlu4, mGlu7, and mGlu8 reveal similar potency at all group III receptors but enhanced potency compared to VU0155094. Increasing concentrations of VU0422288 were applied 2 min prior to the addition of an EC20 concentration of either glutamate (for mGlu4 and mGlu8) or L-AP4 (for mGlu7) in calcium mobilization assays utilizing receptor coexpression with either Gqi5 (mGlu4) or Gα15 (mGlu7 and mGlu8). N = three independent determinations performed in triplicate.