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. 2014 Sep 16;5(12):1221–1237. doi: 10.1021/cn500153z

Figure 7.

Figure 7

VU0155094 and VU0422288 potentiate fEPSP slopes induced by LSP4-2022. (A) Pretreatment of slices with either 1 μM VU0422288 or 30 μM VU0155094 caused a significant decrease in the fEPSP slope compared to application of 30 μM LSP4-2022 alone. (B) Sample traces of baseline fEPSP slopes (1) or in the presence of either VU0155094 or VU0422288 in combination with 30 μM LSP4-2022 (2). Scale bars represent 0.4 mV by 5 ms. (C) Quantification of slope change in response to LSP4-2022 application, VU0155094 or VU0422288 alone, and VU0155094 or VU0422288 and LSP4-2022 application. Data are normalized as percent of baseline slope averaged over either PAM alone or PAM and LSP4-2022 addition (N = 4). **p < 0.01 vs baseline, ***p < 0.001 vs baseline, +p < 0.05 vs LSP4-2022, ++p < 0.01 vs LSP4-2022 (D) Application of VU0155094 or VU0422288 and LSP4-2022 increases the paired-pulse ratio. *p < 0.05 vs baseline.