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. 2014 Dec 10;58(2):814–826. doi: 10.1021/jm501345y

Figure 4.

Figure 4

Effects of compstatin peptides on complement activation in the RPE cell in vitro assay. The ratio of C5b-9/ApoE fluorescence (±SEM, n = 10) is plotted as a percentage of the positive control (POS) for two hfRPE cell lines, 072810 (gray) and 081309 (black). Untreated cells that were not incubated with complement-competent human serum served as negative control (NEG). At 1 μM, the parent compound is not significantly different from the positive or linear peptide controls. All test peptides (W4A9, PEP 5, PEP 8, PEP 12, PEP 18, and PEP 19) displayed significant complement inhibition relative to their corresponding positive control (see Tables S5 and S6).