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. 2014 Dec 18;58(2):994–1004. doi: 10.1021/jm501723p

Figure 2.

Figure 2

Neither His128 nor I218 provides binding specificity of 7 to bsNOS. (A) WT bsNOS–7 with 2FO– FC map contoured at 2.0σ reveals a 3.3 Å H-bond interaction between His128 and the hydroxyl group of 7. (B) H128S-bsNOS–7 crystal structure with 2FO – FC map contoured at 1.5σ. (C) I218V-bsNOS–7 crystal structure with 2FO – FC map contoured at 1.8σ. (D) 2D chemical structure of 7.