Fig. 4.

a) Alternative model architectures for the extrinsic coupling between the primary and secondary sources. FW: forward connectivity; BW: backward connectivity. b) Schematic showing the 16 models we tested. These models correspond to alternative hypotheses about changes in synaptic coupling that can explain changes in spectral activity before and after seizure onset. The 16 models correspond to all combinations of changes in intrinsic connectivity (in the primary and secondary sources) and changes in forward and backward extrinsic connections. The changes in intrinsic connectivity were modelled as changes in the inhibitory recurrent or self connections among superficial pyramidal cells.