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. 1977 Mar;74(3):1229–1233. doi: 10.1073/pnas.74.3.1229

Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.

PMCID: PMC430656  PMID: 300484

Abstract

Mouse spleen cells cocultured with irradiated allogeneic stimulator cells develop cytolytic effector cells capable of lysing 51Cr-labeled syngeneic trinitrophenyl-derivatized tumor or spleen targets and to a lesser degree unconjugated tumor cells in addition to the allogeneic stimulator cells. Lysis of trinitrophenyl-syngeneic targets was inhibited competitively by cold trinitrophenyl-syngeneic tumor or spleen targets as well as by cells bearing the allogeneic stimulator H-2 haplotype demonstrating the immunological specificity of the interaction. Allogeneic H-2 specificities may, therefore, be considered variants of modified autologous H-2 specificities against which cytolytic thymus-derived clones potentially exist that are capable of exerting immunological surveillance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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