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Epinephrine dose-dependent suppression of porcine islet insulin secretion. The epinephrine dose-response was determined under maximal stimulatory conditions for glucose (16.7mM). Mean insulin concentrations (± SEM, pg/islet/h) for the various epinephrine concentrations (x-axis) are presented for four independent islet shipments. Non-linear regression in a log-dose model determined the IC50 to be 60nM.
