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. Author manuscript; available in PMC: 2015 Jan 26.
Published in final edited form as: Biomaterials. 2012 Oct 13;34(1):42–54. doi: 10.1016/j.biomaterials.2012.09.053

Figure 10.

Figure 10

SGN neurite alignment to nano-scale (<1 μm) features. A–B) Cross-sectional SEM images demonstrate the depth of the pattern features compared to the thickness of the polymer film. C) SGN neurites strongly align to patterns with 10 μm periodicities and 250 nm and 500 nm amplitudes (*p < 0.005, one way ANOVA). D) SGN neurite growth extends randomly on unpatterned HMA-co-HDDMA polymers. E–F) SGN neurite growth strongly aligns to patterns with 10 μm periodicities and 250 nm amplitudes (E) as well as to patterns with 50 μm periodicities and 8 μm amplitudes (F). Interestingly, there is no statistical difference (p = 0.369) between SGN neurite alignment on the patterns described in E and F. Cultures were stained with anti-NF200 antibodies (D–F). The pattern is oriented horizontally