Table 2.

SNPs showing interaction with smoking and diabetes with a p value <0.005^*

Gene	SNP	Minor allele	Trait	Interaction analysis		Stratified analysis
				Beta (95% CI)	P	Beta (95% CI)	P	Beta (95% CI)	P
				Current smoking*SNP		Current smoker		Non-current smoker
SIRT1	rs17712705	A	Diastolic diameter	0.34 (0.12, 0.55)	0.002	0.22 (0.03, 0.42)	0.025	−0.07 (−0.16, 0.02)	0.108
			Systolic diameter	0.33 (0.12, 0.54)	0.002	0.22 (0.03, 0.42)	0.025	−0.08 (−0.17, 0.01)	0.086
	rs10997841	G	Diastolic diameter	0.30 (0.10, 0.51)	0.004	0.16 (− −0.04, 0.35)	0.115	−0.09 (−0.17, −0.00)	0.047
			Systolic diameter	0.30 (0.09, 0.50)	0.004	0.15 (−0.04, 0.34)	0.131	−0.09 (−0.18, −0.01)	0.035
	rs7894483	A	Systolic diameter	0.29 (0.09, 0.50)	0.004	0.15 (−0.04, 0.34)	0.123	−0.09 (−0.18, 0.00)	0.042
				Diabetes*SNP		Diabetic		Non-diabetic
SIRT5	rs2253217	C	Strain, log-transformed	−0.20 (−0.32, −0.08)	0.001	−0.13 (−0.25, −0.01)	0.027	0.04 (−0.01, 0.09)	0.122
			Stiffness, log-transformed	0.19 (0.07, 0.31)	0.003	0.12 (0.00, 0.24)	0.053	−0.04 (−0.09, 0.02)	0.188
	rs9382227	T	Strain, log-transformed	−0.21 (−0.33, −0.08)	0.001	−0.11 (−0.24, 0.01)	0.070	0.06 (0.01, 0.11)	0.031
			Stiffness, log-transformed	0.20 (0.07, 0.33)	0.002	0.14 (0.01, 0.26)	0.037	−0.04 (−0.09, 0.02)	0.217
	rs2804918	A	Strain, log-transformed	0.16 (0.05, 0.27)	0.003	0.08 (−0.03, 0.18)	0.161	−0.07 (−0.12, −0.02)	0.007

^*adjusted for age, sex, current smoking, obesity, diabetes, and the top three PCAs.