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. 2014 Dec 23;56(1):1–7. doi: 10.3164/jcbn.14-42

Table 3.

History of superoxide theory of oxygen toxicity

• Discovery of Superoxide dismutase (CuZnSOD); McCord JM, Fridovich I. J Biol Chem 1969; 244: 6049–6055.
• Discovery of Mitochondrial Superoxide dismutase (MnSOD); Weisiger RA, Fridovich I. J Biol Chem 1973; 248: 4793–4796.
• Superoxide (O2•−) is not a strong oxidant; Sawyer DT, Valentine JS. Acc Chem Res 1981; 14: 393–400.
• Endothelium-derived relaxing factor (EDRF) is nitric oxide (NO); Palmer RMJ, Ferrige AG, Moncada S. Nature 1987; 327: 524–526.
• Peroxynitrite (ONOO−) is a potent oxidant and nitrating agent; Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA, Proc Natl Acad U S A 1990; 87: 1620–1624.
• MnSOD protects against cell death: Superoxide induction from mitochondria relates apoptosis; Majima HJ, Oberley TD, Furukawa K, Mattson MP, Yen H-C, Szweda LI, St. Clair D. J Biol Chem 1998; 273: 8217–8224.
• Nobel prize laureates: Murat F, Ignarro L, Furchgott R. 1998.