Fig. 1.

Effect of rebamipide and ampicillin on indomethacin-induced small intestinal mucosal injury in rats. (A) Macroscopic appearance of the mucosal injuries (arrows) in the mid-jejunum 24 h after indomethacin 10 mg/kg p.o. (control, 0.5% CMC). (B) Rebamipide was orally administered five times, 24, 16 and 1 h prior to, and 3 and 7 h after indomethacin administration. Ampicillin was orally administered twice, 24 and 1 h prior to indomethacin administration. **p<0.01 Normal vs Control by t test (two-tailed), ^##p<0.01 Rebamipide vs control by Dunnett test (two-tailed), ^$$p<0.01 ampicillin vs control by t test (two-tailed).