Fig. 3.

Disrupted clock function in Ksrp^−/− mice. A: Locomotor activity of wild-type and Ksrp^−/− mice under a normal 12:12 LD cycle and under DD. Data were plotted in duplicates. B: Free-running periods of wild-type and Ksrp^−/− mice were calculated from A (n = 10 for each group). C: Expression of Per1, Per2, Bmal1, Clock, Cry1, and Cry2 in wild-type and Ksrp^−/− SCN at ZT6 and ZT18 (n = 3 for each genotype and each time point). Data are mean ± SEM. * P < 0.05. D: Food intake of wild-type and Ksrp^−/− mice under a normal 12:12 LD cycle was monitored over three consecutive 24 h cycles. Results are mean ± SEM (n = 6 per genotype).