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LPC(16:0) activated PPARα and PPARα target gene expression. A, B: Evaluation of PPARα activity in luciferase reporter assay (n = 5). Effect of LPC(16:0) on Cpt1a (C), Cpt1b (D), and Aco (E) PPARα target gene expression in wild-type primary hepatocytes (n = 3–4). F–H: Effect of LPC(16:0) on PPARα target gene expression in PPARα−/− primary hepatocytes (n = 6). Data are mean ± SEM. LPC, LPC(16:0).
