TABLE 1.
Brief SAA Expression apoe−/− | Sustained SAA Expression rag1−/− × apoe−/− | |||||
SAA | Null | Saline | SAA | Null | Saline | |
Cholesterol (mg/dl) | 421 ± 74 | 409 ± 34 | 343 ± 49 | 437 ± 53 | 422 ± 50 | 400 ± 52 |
Triglycerides (mg/dl) | 99 ± 17 | 77 ± 10 | 56 ± 11 | 70 ± 12 | 97 ± 18 | 76 ± 15 |
Body weights (g) | 31.4 ± 0.63 | 32.4 ± 0.68 | 32.6 ± 1.19 | 27.0 ± 0.63 | 28.8 ± 0.84 | 29.5 ± 1.4 |
The apoe−/− mice were injected once, or rag1−/− × apoe−/− were injected every 21 days with ad-SAA, ad-Null, or saline and maintained on normal rodent chow for 16 weeks for apoe−/− or 12 weeks for rag1−/− × apoe−/−.