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Comparative sterol biosynthesis pathways across kingdoms showing representative routes to fungal ergosterol (Cryptococcus neoformans associated with AIDS) and protozoan (T. brucei associated with sleeping sickness) and animal cholesterol (Homo sapiens as the human host). Insects do not synthesize sterols as typified by the vector of T. brucei Glossina spp. [adapted from (5–7, 46. Boxed structures represent final products of functional significance.
