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Expression of EP4 receptors and production of PGE2 during consumption of a high-fat diet. A: mRNA expression of EP4 in adipocytes and SVCs from normal (ND, for 16 weeks) or high-fat diet-fed (HFD, for 16 weeks) EP4 wild-type mice. N = 5. *, P < 0.05 ND adipocytes versus HFD adipocytes. B: Amount of PGE2 produced per 0.05 g of adipose tissue in 1 ml media. N = 6; *, P < 0.05 versus 0 weeks. All data are expressed as means ± SEM.
