Fig. 3.

Effect of GPR120 gene invalidation on the conditioned avoidance of LA. Conditioned taste aversion (CTA) performed by pairing a conditioned stimulus, i.e., LA with a digestive pain obtained by intraperitoneal (i.p.) injection of LiCl (150 mM, 16µl/g of body weight), was assessed by using 1 h two-bottle preference tests. Unconditioned controls (GPR120^+/+ and GPR120^−/− mice) received an i.p. NaCl injection. A: LA-mediated CTA. Data shown are the average of two successive tests (48 h interval). There was no inter­action between the tests and no effect of the time. Means ± SEM (n = 7–9). ***, P ≤ 0.001. B: To demonstrate the specificity of LA-taste aversion, two-bottle preference test was performed with sucrose (n = 7–9). Dotted line represents the absence of preference.