TABLE 4.
Fatty acid concentrations in brain glycerophospholipid fractions
| Concentration (nmol/g Brain) | ||||||||
| ChoGpl | EtnGpl | PtdIns | PtdSer | |||||
| Fatty Acid | Adequate | Deprived | Adequate | Deprived | Adequate | Deprived | Adequate | Deprived |
| 14:0 | 103.9 ± 1.7 | 124.8 ± 2.5a | 9.4 ± 0.4 | 11.2 ± 0.6a | 2.3 ± 0.3 | 3.1 ± 0.4 | 4.5 ± 0.6 | 4.5 ± 0.2 |
| 14:1n-7 | ND ± ND | ND ± ND | ND ± ND | ND ± ND | ND ± ND | ND ± ND | ND ± ND | ND ± ND |
| 16:0 | 13,546.8 ± 113.2 | 13,764.7 ± 203.2 | 1,794.0 ± 21.2 | 1,806.2 ± 51.6 | 267.6 ± 19.8 | 275.8 ± 20.4 | 189.1 ± 5.4 | 177.6 ± 4.2 |
| 16:1 n-7 | 147.2 ± 1.9 | 182.1 ± 4.6a | 282.3 ± 118.8 | 218.7 ± 86.6 | 5.2 ± 0.3 | 6.7 ± 0.5a | 7.2 ± 0.1 | 8.8 ± 0.3a |
| 18:0 | 3,573.1 ± 22.4 | 3,639.3 ± 44.5 | 5,059.1 ± 148.8 | 4,869.2 ± 146.1 | 562.1 ± 62.2 | 559.9 ± 55.0 | 4,090.8 ± 85.9 | 4,138.7 ± 85.2 |
| 18:1 n-9 | 5,987.7 ± 71.3 | 6,617.8 ± 88.7a | 2,975.5 ± 144.9 | 3,307.7 ± 192.1 | 407.4 ± 13.9 | 455.9 ± 17.3 | 2,059.9 ± 43.0 | 2,260.8 ± 56.8a |
| 18:1 n-7 | 1,448.1 ± 8.2 | 1,394.1 ± 65.8 | 754.7 ± 9.8 | 838.3 ± 29.4a | 89.1 ± 4.3 | 90.9 ± 5.2 | 154.0 ± 3.1 | 156.4 ± 3.9 |
| 18:2 n-6 | 192.9 ± 2.3 | 126.8 ± 1.9a | 92.4 ± 3.6 | 66.0 ± 2.4a | 18.6 ± 0.8 | 14.0 ± 0.8a | 18.0 ± 0.7 | 14.6 ± 1.2a |
| 18:3 n-6 | 9.1 ± 0.3 | 9.2 ± 0.2 | 10.4 ± 0.6 | 9.3 ± 0.6 | 1.6 ± 0.1 | 1.5 ± 0.1 | 8.4 ± 0.2 | 8.2 ± 0.2 |
| 18:3 n-3 | 8.5 ± 0.4 | 9.4 ± 1.0 | 17.4 ± 1.7 | 17.2 ± 1.9 | 1.1 ± 0.1 | 1.1 ± 0.1 | 3.3 ± 0.1 | 2.9 ± 0.1a |
| 20:0 | 55.6 ± 1.0 | 54.4 ± 1.1 | 78.9 ± 1.1 | 61.6 ± 2.5a | 11.4 ± 0.3 | 10.9 ± 0.3 | 48.3 ± 1.2 | 50.1 ± 1.5 |
| 20:1 n-9 | 286.6 ± 5.8 | 289.6 ± 5.5 | 755.6 ± 104.8 | 902.5 ± 35.1 | 54.1 ± 1.7 | 48.1 ± 4.6 | 233.8 ± 7.4 | 225.1 ± 8.7 |
| 20:3 n-3 | 44.3 ± 0.7 | 72.0 ± 1.1a | 117.2 ± 4.6 | 123.4 ± 3.2 | 9.2 ± 0.4 | 11.2 ± 0.7a | 42.3 ± 0.7 | 50.4 ± 1.1a |
| 20:4 n-6 | 1,441.0 ± 20.7 | 1,147.5 ± 16.7a | 3,419.4 ± 21.6 | 2,693.5 ± 64.9a | 368.9 ± 57.8 | 337.6 ± 53.9 | 321.3 ± 3.0 | 248.5 ± 6.0a |
| 22:0 | 9.2 ± 1.0 | 8.5 ± 0.7 | 5.3 ± 0.3 | 5.5 ± 0.3 | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.6 ± 0.0 | 0.6 ± 0.0 |
| 20:5 n-3 | 2.1 ± 0.4 | 22.6 ± 0.6a | 3.3 ± 0.2 | 43.3 ± 1.3a | 1.6 ± 0.6 | 4.8 ± 0.7a | 1.5 ± 0.4 | 3.9 ± 0.3a |
| 22:1 n-9 | 36.7 ± 4.7 | 40.8 ± 1.4 | 53.4 ± 1.2 | 43.1 ± 2.0a | 10.8 ± 0.3 | 10.6 ± 0.3 | 48.2 ± 1.2 | 52.8 ± 1.8 |
| 22:4 n-6 | 171.7 ± 2.6 | 114.6 ± 1.6a | 1,472.7 ± 30.2 | 917.8 ± 23.0a | 35.0 ± 1.6 | 23.0 ± 1.3a | 296.8 ± 3.2 | 194.3 ± 5.2a |
| 22:5 n-6 | 19.7 ± 0.6 | 8.7 ± 0.2a | 94.0 ± 2.5 | 44.8 ± 0.7a | 2.1 ± 0.2 | 0.9 ± 0.0a | 48.1 ± 0.6 | 23.9 ± 0.5a |
| 22:5 n-3 | 18.5 ± 0.3 | 38.1 ± 1.0a | 68.4 ± 1.5 | 177.0 ± 5.5a | 1.5 ± 0.1 | 4.1 ± 0.3a | 16.6 ± 0.1 | 40.6 ± 1.3a |
| 22:6 n-3 | 1,017.0 ± 18.9 | 1,137.0 ± 22.6a | 4,575.3 ± 106.9 | 4,865.7 ± 92.1 | 92.4 ± 6.9 | 102.6 ± 7.6a | 1,776.1 ± 12.6 | 1,940.2 ± 37.6a |
| 24:1 n-9 | 41.6 ± 4.2 | 46.1 ± 2.1 | 38.7 ± 1.8 | 31.2 ± 2.4a | 11.9 ± 0.3 | 12.4 ± 0.4 | 34.2 ± 0.6 | 39.1 ± 1.4 |
Brain fatty acid concentrations in phospholipid fractions of baseline uninfused rats after 15 weeks of feeding (n = 8 per dietary group). Data are means ± SEM.
a
Indicates significant difference from the adequate n-6 PUFA group (P < 0.05).