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. 2015 Feb;145(2):93–106. doi: 10.1085/jgp.201411304

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© 2015 Moreau et al.

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Figure 1. — The R222Q residue is highly conserved among ion channels. (A) Schematic 2-D representation of the 24-transmembrane segments of Na_v1.5 organized in four homologous domains. The red circles indicate the locations of the R222Q and R225W mutations. (B) The S4 segments of the first domains of the Na_v1.5, Na_v1.4, and Ca_v1.1 channels, and the S4 segments of the Na_vAb and Shaker channels were aligned using CLC sequence viewer 6 (QIAGEN). Positively charge residues (arginines or lysines) are numbered from R0 to R7 and bolded in blue. The R2 and R3 indicated by the red arrow correspond to R222Q and R225W in Na_v1.5.