Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb;145(2):93–106. doi: 10.1085/jgp.201411304

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Moreau et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 8. — The gating pore current generated by R222Q and R225W mutations is permeant in both activated and resting states. The VSD of domain I of mutated Na_v1.5 is shown in their resting (green), activated (red), and immobilized (orange) states. These states are represented during the cardiac AP. The gating pore permeation pathway is open during the plateau phase of the AP, leading to an outward K⁺ leak and an inward Na⁺ leak. Because of S4 immobilization, the gating pore is also permeant to Na⁺ at the end of the AP.