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. 2015 Feb;145(2):155–162. doi: 10.1085/jgp.201411268

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© 2015 Martin-Eauclaire et al.

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Figure 4. — CssIV interacts with the rNa_v1.2a VSD II paddle motif. Shown is the effect of 1 µM CssIV on the rNa_v1.2a/K_v2.1 VSD II and IV paddle chimera. Normalized tail current voltage–activation relationships in which the tail current amplitude (I/I_max) is plotted against test voltage (V) before (black) and in the presence of toxin (red/green) are displayed. A Boltzmann fit of the obtained data (n = 3; error bars represent mean ± SEM) reveals a depolarizing shift in V_1/2 of ∼14 mV (from 33 ± 2 mV to 47 ± 1 mV) for the VSD II chimera, whereas 1 µM CssIV does not influence the VSD IV chimera. Holding voltage was −90 mV, and the tail voltage was −60 mV.