Table 2.
Residues of the influenza A virus M1 middle domain bound by the residues and domains of the human scFv21.
| Influenza A M1 Middle Domain | Human scFv21 | Intermolecular Bond | ||
|---|---|---|---|---|
| Amino Acid | Motif | Amino Acid | Domain | |
| H110 | Helix 7 | P106 | VH-CDR3 | Hydrophobic |
| H110 | Helix 7 | M188 | VL-FR3 | Hydrophobic |
| K113 | Helix 7 | N100 | VH-CDR3 | Hydrogen |
| K113 | Helix 7 | T101 | VH-CDR3 | Hydrogen |
| E114 | Helix 7 | Y27 | VH-CDR1 | Hydrogen |
| E114 | Helix 7 | Y32 | VH-CDR1 | Hydrogen |
| E114 | Helix 7 | N100 | VH-CDR3 | Hydrogen |
| L117 | Helix 7 | W33 | VH-CDR1 | Hydrophobic |
| S118 | Between helices 7 and 8 | N31 | VH-CDR1 | Hydrogen |
| E152 | Helix 9 | T101 | VH-CDR3 | Hydrogen |
| E152 | Helix 9 | R182 | VL-FR2 | Salt-bridge |
| D156 | Helix 9 | Y52 | VH-CDR2 | Hydrogen |
| D156 | Helix 9 | Y52 | VH-CDR2 | Hydrogen |
| R163 | Helix 9 | S103 | VH-CDR3 | Hydrogen |