Table 1.

Cell lines permissive to prion infection.

Cell Designation	Species	Tissue or Cell of Origin	Prion Strain	References
Neuronal
N2a	Mouse	Neuroblastoma	Chandler, RML, 139A, 22L, C506, Fukuoka-1, FU CJD	[11,12,30,31]
GT1	Mouse	Hypothalamic	Chandler, RML, 139A, 22L, FU CJD, M1000	[30,32]
SMB	Mouse	Scrapie-infected mesodermal cells	Chandler, 139A, 22F, 79A	[30,33,34]
SN56	Mouse	Cholinergic septal cells	Chandler, ME7, 22L	[35]
CAD	Mouse	Catecholaminergic	RML, 22L, ME7, 301C	[14]
PC12	Rat	Pheochromocytoma	139A, ME7	[36,37]
Non-Neuronal Cell Lines
C2C12	Mouse	Myotubes	RML, ME7, 22L	[38,39]
NIH/3T3	Mouse	Fibroblast	22L	[40]
moRK13	Rabbit	Epithelial cell line expressing mouse PrPC	22L, Chandler, M1000, mo sCJD, Fukuoka-1	[41,42]
voRK13	Rabbit	Epithelial cell line expressing vole PrPC	vole-adapted BSE	[41]
ovRK13/ RoV9	Rabbit	Epithelial cell line expressing ovine PrPC	PG127, LA404, SSBP/1, scrapie field isolates	[43,44]
SSCA Cell Lines
PK1	Mouse	N2a	RML, 22L	[45,46,47]
R33	Mouse	N2a	RML, 22L	[14,46]
CAD5	Mouse	CAD	RML, 22L, ME7, 301C	[14,46]
LD9	Mouse	L929	RML, 22L, ME7	[14,46]
L929	Mouse	Fibroblast	RML, 22L, ME7	[40]
Elk21-	Rabbit	RK13: epithelial cell line expressing elk PrPC	CWD	[48]