Figure 1. Circular RNA expression from RNA-seq data of normal colon mucosa (Normal) and colorectal carcinoma (Carcinoma) samples.

(a) Expression levels of all biuniquely annotatable and reliably quantifiable 85 circular RNAs in twelve matched normal and carcinoma samples; normalised log₂ values were averaged among the samples (p<2.2e-16). (b) Expression levels of reliably quantifiable 260 circular RNAs in pooled normal and carcinoma samples; log₂ values were normalised to total sequencing read numbers (p<2.2e-16). Significance was assessed by paired student's t-tests (2.2e-16 is the minimum value of the used test in R).