Figure 5. Liver tumor development was enhanced in the 2PLEASE model by the suppression of wild-type p53.

(A) Bioluminescence imaging of 2PLEASE mice was performed at 1 and 7 weeks post-hydrodynamic delivery of transposons co-expressing shp53 and Cre. Gross morphologies of livers harvested at the time points are shown below. (B) Green fluorescence imaging of a representative tumor harvested at 7 weeks post-hydrodynamic injection (left panel) and H&E staining of the tumor (right panel). Scale bars, 200 μm.