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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: Neurobiol Dis. 2014 Mar 6;66:92–103. doi: 10.1016/j.nbd.2014.02.012

Fig. 6.

Fig. 6

The endocytic pathway is impaired in Twitcher DRG neurons. (A) Density of early endosomes in DRG neurons of WT and Twitcher (twi) mice. (B) Percentage of TrkA+ early endosomes (Rab 5+ vesicles) in DRG from WT and twi mice. (C) mRNA expression level of TrkA in DRG of WT and twi mice. (D) Velocity of retrograde and anterograde axonal transport of lysosomes in DRG neurites from WT and twi mice. (E) Percentage of stationary lysosomes and lysosomes with retrograde or anterograde movement in DRG neurites from WT and twi mice. (F) Density of lysosomes in DRG from WT and twi mice. (G) Kymographs depicting the movement of lysosomes in WT and twi neurites. (H) Velocity of retrograde and anterograde axonal transport of synaptophysin+ vesicles in DRG neurons of WT and twi mice. (I) Kymographs depicting the movement of synaptophysin+ vesicles in WT and twi axons.