Table 4.

Glucocorticoid replacement therapy in adrenal sufficiency

Condition	Hydrocortisone	Prednisone	Dexametha -Sone
Daily dose (oral)	15–25 mg daily in divided doses	3–5 mg daily in divided doses	0.375 to 0.75 mg daily in one dose
Minor stress (cold) Oral	30–50 mg/daily in 3 divided doses for 2–3 days	8–15 mg/daily in 2 divided doses for 2–3 days	1 to 2 mg/d in 2 divided doses for 2–3 days
Moderate stress (minor or moderate surgical procedure) oral or intravenous	45–75 mg/daily in 3 divided doses for 2–3 days	15–20 mg/daily in 2 divided doses for 2–3 days	2–3 mg/d in 2 divided doses for 2–3 days
Severe stress (major surgery/sepsis)	100–200 mg/daily in 4 divided doses for 1 day taper to physiological dose over 3–5 days	Same as hydrocortisone regimen	Follow hydro-cortisone regimen
Septic shock	150–200 mg/daily in 4 divided doses, taper as clinically tolerated	Follow hydrocortisone regimen	Follow hydro –cortisone regimen

Adapted from

ref. ¹⁹

Oelkers et al.;²⁰

Debono et al.;²¹