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Sulfhydration of the E3 ubiquitin ligase parkin is affected in Parkinson's disease (PD). Under normal conditions, parkin, an E3 ubiquitin ligase, ubiquitinates diverse substrates and targets them for proteosomal degradation. The activity is enhanced by sulfhydration. In PD, diminished sulfhydration of parkin results in lower catalytic activity, leading to accumulation of target proteins and neurotoxicity.
