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. 2015 Jan 16;16(1):4. doi: 10.1186/s12931-014-0162-6

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© Sureshbabu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TGFβ1 signaling in NB TGFβ1TG, and TGFβ1TG X TGFβR2KO mice lungs. (A) Western blot analysis showed upregulation of phospho AKT, and down regulation of ANGPT2, and pro-apoptotic proteins (BAX; cleaved caspase 3) in NB TGFβ1TG X TGFβR2KO lungs as compared to TGFβ1TG mice. (B) Densitometric analysis showed increased ANGPT1 to ANGPT2 ratio in maternal dox exposed NB TGFβ1TG X TGFβR2KO lungs as compared to TGFβTG mice. N = 3, in each group; *p < 0.05.