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. 2015 Jan 2;16(1):924–949. doi: 10.3390/ijms16010924

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Sphingolipid metabolism. Ceramide is a key intermediator in sphingolipid metabolism. The enzymes involved in sphingolipid metabolism are ceramidase (Case), ceramide kinase (CK), ceramide-1-phophosphate phosphatase (CPP), ceramide synthase (CS), dihydroceramide desaturase (DD), galactosylceramide synthase (GalCS), galactocer (GalC), glucosylceramide synthase (GCS), glucosylceramidase (Gcase), sphingomyelinase (Smase), and sphingomyelin synthase (SMS). Many of these products play an important role in cell signaling which regulates a variety of cellular functions. SMS converts phosphatidylcholine (PC) and ceramide to sphingomyelin and diacylglycerol which brings two major classes of lipids in cell metabolism and signaling.