Figure 2.

Schematic representing pathway mechanisms that regulate the cell surface expression of TF. Mechanisms identified in the current study that increase TF in the BioMAP 3C system and regulate autophagy by impacting nutrient, oxygen, lipid or bacterial sensing functions as detailed in the text. The process of autophagy involves nucleation of autophagosomes, engulfment of cellular constituents, fusion with lysosomes, and subsequent degradation of the contents.