Table 1.
List of test agents that increase cell surface levels of TF in the BioMAP 3C system, their mechanism class if known, the likelihood that the indicated mechanism class is involved in the regulation of TF (as described in the text), active concentrations (in nM unless otherwise listed) and the source of experimental data. Note that data for all compounds are included in Supplemental Table S3. Test agents listed increase TF >30% at two or more concentrations as described in the Experimental Section.
| Compound Name | Mechanism | Likelihood of Mechanism Involvement | Concentrations Active (nM) | Data Source |
|---|---|---|---|---|
| 2-Mercaptobenzothiazole | AhR agonist | Probable | 13,000, 40,000 | Reference [1] |
| 3-Hydroxyfluorene | AhR agonist | Probable | 4400, 13,000, 40,000 | Reference [1] |
| Benzo(b)fluoranthene | AhR agonist | Probable | 4400, 13,000, 40,000 | Reference [1] |
| C.I Solvent yellow 14 | AhR agonist | Probable | 13,000, 40,000 | Reference [1] |
| FICZ | AhR agonist | Probable | 0.15, 0.46, 1.4, 4.1, 12, 37, 111, 333, 1000 | This study |
| Abiraterone | CYP17A Inhibitor | Probable | 1100, 3300, 10,000 | This study |
| Ketoconazole | CYP17A Inhibitor | Probable | 3300, 10,000 | This study |
| Clomiphene citrate | Estrogen R Antagonist | Probable | 2100, 4200 | Reference [1] |
| Histamine | H1R agonist | Probable | 370, 1100, 3300, 10,000, 30,000, 90,000 | This study |
| Histamine Phosphate | H1R agonist | Probable | 1111, 3300, 10,000, 30,000 | This study |
| Cobalt(II) Chloride Hexahydrate | HIF-1α Inducer | Probable | 30,000, 100,000 | This study |
| Tin(II) Chloride | HIF-1α Inducer | Probable | 10,000, 30,000 | This study |
| Chloroquine Phosphate | Lysosome Inhibitor | Probable | 10,000, 30,000 | This study |
| Primaquine Diphosphate | Lysosome Inhibitor | Probable | 11,000, 33,000 | This study |
| Temsirolimus | mTOR Inhibitor | Probable | 0.51, 1.5, 4.6, 123 | This study |
| Torin-1 | mTOR Inhibitor | Probable | 0.46, 1.4, 4.1, 12, 37 | This study |
| Torin-2 | mTOR Inhibitor | Probable | 0.46, 1.4, 4.1, 12 | This study |
| Bryolog | PKC activator | Probable | 4, 12, 37, 110, 330, 1000 | This study |
| Bryostatin 1 | PKC activator | Probable | 12, 37, 110, 330, 1000 | This study |
| Bryostatin 2 | PKC activator | Probable | 0.15, 0.46, 1.4, 4.1, 12, 37, 111 | This study |
| Phorbol 12-myristate 13-acetate | PKC activator | Probable | 37, 41, 111, 120, 330, 370, 1000, 1100, 3300 | This study |
| Phorbol 12,13-didecanoate | PKC activator | Probable | 1.5, 4.6, 14, 41, 123, 370, 1100, 3300 | This study |
| Picolog | PKC activator | Probable | 3.7, 11, 33, 100 | This study |
| Z-FA-FMK | Cysteine protease Inhibitor | Possible | 1100, 3300, 10,000, 30,000 | This study |
| Mifamurtide | NOD2 agonist | Possible | 1111, 3300, 10,000, 30,000 | This study |
| Ethanol | Organic Solvent | Possible | 0.3%, 0.9% | This study |
| Oncostatin M | OSM R agonist | Possible | 0.037, 0.11, 0.33, 3 | This study |
| PAz-PC | Oxidized phospholipid | Possible | 10,000, 30,000 | This study |
| 3,5,3-Triiodothyronine | Thyroid H R agonist | Possible | 16,000, 32,000 | Reference [1] |
| Concanamycin A | Vacuolar ATPase Inhibitor | Possible | 0.14, 0.41, 1.2, 3.7, 11, 33, 100 | This study |
| MK-2206 | AKT Inhibitor | Unknown | 1111, 3300, 10,000 | This study |
| Crizotinib | ALK, c-met Inhibitor | Unknown | 1111, 3333 | This study |
| N-Ethylmaleimide | Alkylating agent | Unknown | 37, 110 | This study |
| Terconazole | Anti-fungal | Unknown | 9300, 9400 | This study |
| GDC-0879 | B-Raf Inhibitor | Unknown | 370, 1100 | This study |
| KN93 | CAMKII Inhibitor | Unknown | 1100, 3300 | This study |
| 8-Hydroxyquinoline | Chelating agent | Unknown | 18, 55 | Reference [1] |
| Linoleic Acid Ethyl Ester | Fatty Acid | Unknown | 10,000, 30,000, 90,000, 270,000 | This study |
| Tris(1,3-dichloro-2-propyl) phosphate | Flame retardant | Unknown | 13,000, 40,000 | Reference [1] |
| Fenaminosulf | Fungicide | Unknown | 13,000, 40,000 | Reference [1] |
| Mancozeb | Fungicide | Unknown | 20,000, 40,000 | Reference [1] |
| Primidone | GABA R agonist | Unknown | 1500, 4400 | This study |
| Mometasone furoate | GR agonist | Unknown | 1111, 3300 | This study |
| Desloratadine | H1R antagonist | Unknown | 10,000, 30,000 | This study |
| A 205804 | ICAM, E-selectin inhibitor | Unknown | 41, 123 | This study |
| Dodecylbenzene | Industrial chemical | Unknown | 1200, 2500 | Reference [1] |
| UO126 | MEK Inhibitor | Unknown | 4.6, 14, 41 | This study |
| Imatinib | PDGFR, c-Kit, Bcr-Abl Inhibitor | Unknown | 3300, 10,000 | This study |
| ZK-108 | PI-3K Inhibitor (βγ-selective) | Unknown | 1100, 3300, 10,000 | This study |
| GW9662 | PPARγ agonist | Unknown | 7400, 22,000 | This study |
| PP3 | SRC Kinase Inhibitor | Unknown | 3300, 10,000, 30,000 | This study |
| TX006146 | Unknown | Unknown | 13,000, 40,000 | Reference [1] |
| TX006237 | Unknown | Unknown | 1500, 4400 | Reference [1] |
| TX011661 | Unknown | Unknown | 5000, 10,000, 20,000 | Reference [1] |
| U-73343 | Unknown | Unknown | 560, 1700 | This study |