Table 2.

List of target agonist and antagonist pairs that modulate cell surface levels of TF in the BioMAP 3C system in a reciprocal manner. Test agents listed increase TF at two or more concentrations as described in the Experimental Section, or significantly decrease the level of TF as indicated.

Target Class	Action	Compound	TF Level	Reference
AhR	Agonist	2-Mercaptobenzothiazole	Increased	This study
AhR	Agonist	3-Hydroxyfluorene	Increased	This study
AhR	Agonist	Benzo(b)fluoranthene	Increased	This study
AhR	Agonist	C.I Solvent yellow 14	Increased	This study
AhR	Agonist	FICZ	Increased	Reference [21]
AhR	Antagonist	CH223191	Decreased	Unpublished, 2014
ER	Antagonist	Clomiphene citrate	Increased	This study
ER	Agonist	17α-Ethynylestradiol	Decreased	Reference [21]
ER	Agonist	17β-Estradiol	Decreased	Reference [21]
ER	Antagonist	Tamoxifen	Increased	Reference [1]
ER	Antagonist	Tamoxifen Citrate	Increased	Reference [1]
ER	Antagonist	Fulvestrant	Increased	Reference [1]
ER	Antagonist	Raloxifene hydrochloride	Increased	Reference [1]
H1R	Antagonist	Astemizole	Decreased	Reference [21]
H1R	Antagonist	Ketotifen Fumarate	Decreased	Reference [21]
H1R	Antagonist	trans-Triprolidine	Decreased	Reference [21]
H1R	Agonist	Histamine	Increased	This study
H1R	Agonist	Histamine Phosphate	Increased	This study
PKC	Activator	Bryolog	Increased	This study
PKC	Activator	Bryostatin	Increased	This study
PKC	Activator	Bryostatin 1	Increased	This study
PKC	Activator	Phorbol 12-myristate 13-acetate	Increased	This study
PKC	Activator	Phorbol 12,13-didecanoate	Increased	This study
PKC	Activator	Picolog	Increased	This study
PKC	Inhibitor	GF 109203X	Decreased	Reference [21]
PKC	Inhibitor	Go 6983	Decreased	Reference [21]
PKC	Inhibitor	Ro-32-0432	Decreased	Reference [21]