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. 2015 Jan 8;16(1):1406–1428. doi: 10.3390/ijms16011406

Figure 1.

Figure 1

Overall structure of SET and MYND domain-containing proteins (SMYD) proteins. (A) Domain diagram of SMYD protein family. S, S-sequence; MYND (Myeloid, Nervy, DEAF1); SET-I, insertion SET (Su(Var)3-9, Enhancer-of-zeste, Trithorax) domain; (S)ET, core SET domain; Post-SET, SET C-terminal flanking domain; CTD, C-terminal domain; (B) Ribbon diagram of SMYD1 (PDB code: 3N71), SMYD2 (PDB code: 3QWV and 3QWW), and SMYD3 (PDB code: 3PDN). The S-sequence, MYND, SET-I, core SET, post-SET, and CTD are depicted in light green, blue, pink, green, cyan, and red. Secondary structures, α-helices and β-strands are labeled and numbered according to their position in the sequence. Cofactors, sinefungin (SFG) and S-adenosyl-l-homocysteine (SAH), are depicted in balls and sticks; and (C) Structural superposition of SMYD proteins: SMYD1 (magenta), SMYD2 (SFG, cyan; SAH, green), and SMYD3 (yellow). The superposition is based on the N-terminal lobe.