Figure 3.
Cofactor binding pocket. (A) Surface representation of the cofactor-binding pocket of SMYD1–3, SET7 (PDB code: 1O9S), and Dim-5 (PDB code: 1PEG). The surface of SMYD proteins is colored according to domains. Bound SAH or SFG is depicted by sticks with the carbon atoms colored in white; (B) Superposition of the cofactor binding sites. SMYD residues are represented by sticks with the carbon atoms colored according to the scheme in Figure 1C. Cofactor is depicted by balls-and-sticks overlaid with translucent molecular surface.