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. 2015 Jan 14;16(1):1821–1839. doi: 10.3390/ijms16011821

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme for pathways of glucose metabolism. The scheme is based on enzyme activities, metabolites and molecular changes in BME26 cells after glucose treatments. The enzymes studied are presented inside blue spheres (HK, PK, GS, GSK3, PGM, GDE, PEPCK and GP). Arrows next to the enzymes (↓↑) represent the oscillations in enzymatic activity and transcriptional response. Small spheres next enzymes (○) indicate no variations in these enzymes or genes compared with the control. Dashed line involves several enzymes steps in the pathway, and solid lid represents one enzymatic step. The low-glucose (B) and high-glucose (C) are compared with the control (A).