Table 2.
Significant interaction of SNPs × diagnosis and quantitative trait (DMS-TC) in DMS.
| CHR | SNP | Position | Type | Gene | Traits | p |
|---|---|---|---|---|---|---|
| 10 | rs1411832 | 107886255 | Intergenic | Downstream of YWHAZP5 | DMS-TC | 2.02 × 10−7 |
| 20 | rs61131853 | 41749812 | Intron | PTPRT | DMS-TC | 7.10 × 10−7 |
| 18 | rs79589976 | 73305576 | Intron | TADA2L | DMS-TC | 1.51 × 10−6 |
| 13 | rs74108723 | 90358757 | Intergenic | N/A | DMS-TC | 1.64 × 10−6 |
| 10 | rs10999524 | 72525761 | intergenic | Upstream of C10orf27 | DMS-TC | 1.95 × 10−6 |
| 7 | rs4718138 | 64303065 | Intron | ZNF138 | DMS-TC | 2.15 × 10−6 |
| 11 | rs1552511 | 92605986 | Intron | FAT3 | DMS-TC | 2.31 × 10−6 |
| 11 | rs555329 | 95993708 | Intron | FAT3 | DMS-TC | 2.41 × 10−6 |
| 18 | rs2868934 | 10204383 | Intron | TADA2L | DMS-TC | 2.56 × 10−6 |
| 7 | rs60569161 | 98199903 | intergenic | Upstream of NPTX2 | DMS-TC | 3.62 × 10−6 |
| 10 | rs7899885 | 70143774 | Intron | RUFY2 | DMS-TC | 5.02 × 10−6 |
| 12 | rs12811916 | 25550866 | Intron | DSCAML1 | DMS-TC | 5.33 × 10−6 |
| 10 | rs2281698 | 70104320 | Intron | RUFY2 | DMS-TC | 5.42 × 10−6 |
| 16 | rs4780688 | 17567540 | intergenic | Downstream of XYLT1 | DMS-TC | 5.84 × 10−6 |
| 21 | rs76659985 | 26786931 | Intron | LINC00158 | DMS-TC | 6.13 × 10−6 |
| 1 | rs3738516 | 43440201 | Intron | Downstream of SLC2A1 | DMS-TC | 6.19 × 10−6 |
| 3 | rs17609699 | 60487578 | Intron | FHIT | DMS-TC | 6.20 × 10−6 |
| 16 | rs4785000 | 58963145 | intergenic | Upstream of LOC100132798 | DMS-TC | 6.51 × 10−6 |
| 11 | rs630024 | 117534353 | Intron | MAML2 | DMS-TC | 8.09 × 10−6 |
| 10 | rs3781567 | 70105178 | Intron | RUFY2 | DMS-TC | 8.11 × 10−6 |
| 10 | rs1162753 | 70105560 | synonymous | RUFY2 | DMS-TC | 8.11 × 10−6 |
| 10 | rs17297439 | 70103461 | Intron | RUFY2 | DMS-TC | 8.11 × 10−6 |
| 10 | rs3199937 | 70102749 | Intron | RUFY2 | DMS-TC | 8.11 × 10−6 |
| 10 | rs3781568 | 70105286 | Intron | HNRNPH3 | DMS-TC | 8.11 × 10−6 |
| 10 | rs7897488 | 70179746 | Intron | RUFY2 | DMS-TC | 8.11 × 10−6 |
| 10 | rs7071140 | 70100250 | Intron | HNRNPH3 | DMS-TC | 8.42 × 10−6 |
| 19 | rs7249563 | 7009813 | intergenic | Downstream of VAPA | DMS-TC | 8.85 × 10−6 |
| 18 | rs652630 | 34899378 | Intron | CELF4 | DMS-TC | 9.70 × 10−6 |
| 2 | rs520102 | 220529636 | intergenic | Downstream of SLC4A3 | DMS-TC | 1.11 × 10−5 |
| 15 | rs2453034 | 101241344 | Intron | NPAS3 | DMS-TC | 1.17 × 10−5 |
| 16 | rs6499996 | 58993725 | intergenic | Downstream of XYLT1 | DMS-TC | 1.17 × 10−5 |
| 3 | rs6773944 | 54516884 | Intron | CACNA2D3 | DMS-TC | 1.23 × 10−5 |
| 17 | rs2322973 | 13699188 | intergenic | Downstream of LOC644649 | DMS-TC | 1.33 × 10−5 |
| 7 | rs58908055 | 83788680 | Intron | SEMA3A | DMS-TC | 1.38 × 10−5 |
| 16 | rs9930442 | 58978493 | intergenic | Downstream of LOC644649 | DMS-TC | 1.45 × 10−5 |
| 5 | rs59017736 | 26250801 | intergenic | Downstream of MSNL1 | DMS-TC | 1.56 × 10−5 |
| 4 | rs4470690 | 188721512 | intergenic | Downstream of LOC644325 | DMS-TC | 1.57 × 10−5 |
| 17 | rs8067120 | 35783565 | Intron | TADA2A | DMS-TC | 1.58 × 10−5 |
| 15 | rs1458888 | 35406129 | Intron | NPAS3 | DMS-TC | 1.60 × 10−5 |
| 1 | rs1286830 | 62270494 | Intron | INADL | DMS-TC | 1.64 × 10−5 |
| 16 | rs8060933 | 65891108 | intergenic | Downstream of LOC644649 | DMS-TC | 1.67 × 10−5 |
| 7 | rs705337 | 98226627 | intergenic | Upstream of NPTX2 | DMS-TC | 1.68 × 10−5 |
| 20 | rs6030661 | 41748131 | Intron | PTPRT | DMS-TC | 1.70 × 10−5 |
| 6 | rs4708759 | 169005721 | Intron | SMOC2 | DMS-TC | 1.76 × 10−5 |
| 16 | rs12373039 | 65894066 | intergenic | Downstream of LOC644649 | DMS-TC | 1.80 × 10−5 |
| 1 | rs1286831 | 62271962 | Intron | INADL | DMS-TC | 1.81 × 10−5 |
| 14 | rs78636353 | 88681552 | Intron | KCNK10 | DMS-TC | 1.84 × 10−5 |
| 3 | rs614673 | 118539108 | intergenic | Upstream of IGSF11 | DMS-TC | 1.87 × 10−5 |
| 15 | rs28436697 | 27624233 | Intron | GABRG3 | DMS-TC | 1.92 × 10−5 |
| 4 | rs77470375 | 83823703 | Intron | THAP9 | DMS-TC | 1.98 × 10−5 |
| 5 | rs2066960 | 131994435 | Intron | IL13 | DMS-TC | 2.08 × 10−5 |
| 20 | rs6132627 | 23444688 | Intron | LGALS4 | DMS-TC | 2.08 × 10−5 |
| 4 | rs62303604 | 82397503 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 4 | rs16998600 | 82403384 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 4 | rs62302363 | 82417252 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 4 | rs17005142 | 82402588 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 4 | rs17005144 | 82404274 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 4 | rs6819741 | 82403942 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.17 × 10−5 |
| 15 | rs2575426 | 96405795 | intergenic | Downstream ofLOC441722 | DMS-TC | 2.22 × 10−5 |
| 16 | rs12931857 | 58967112 | intergenic | Upstream of CDH5 | DMS-TC | 2.25× 10−5 |
| 3 | rs80028372 | 118805552 | Intron | IGSF11 | DMS-TC | 2.26 × 10−5 |
| 4 | rs7438406 | 99702148 | intergenic | Downstream of BTF3L3 | DMS-TC | 2.28 × 10−5 |
| 20 | rs2325606 | 41738666 | Intron | PTPRT | DMS-TC | 2.33 × 10−5 |
| 3 | rs17659192 | 3108711 | Intron | IL5RA | DMS-TC | 2.41 × 10−5 |
| 3 | rs12630657 | 118842442 | Intron | IGSF11 | DMS-TC | 2.43 × 10−5 |
| 4 | rs10034975 | 122175499 | intergenic | Upstream of GPR103 | DMS-TC | 2.46 × 10−5 |
| 9 | rs7041922 | 34938198 | intergenic | Upstream of KIAA1045 | DMS-TC | 2.49 × 10−5 |
| 2 | rs6544074 | 37634473 | intergenic | Downstream of QPCT | DMS-TC | 2.52 × 10−5 |
| 4 | rs10015146 | 82401332 | intergenic | Downstream of RASGEF1B | DMS-TC | 2.65 × 10−5 |
| 6 | rs2744229 | 25341580 | Intron | LRRC16A | DMS-TC | 2.71 × 10−5 |
| 12 | rs12318900 | 66044284 | intergenic | Upstream of KRAS | DMS-TC | 2.72 × 10−5 |
| 15 | rs9708085 | 27619217 | Intron | GABRG3 | DMS-TC | 2.83 × 10−5 |
| 5 | rs6894424 | 34732456 | Intron | RAI14 | DMS-TC | 2.85 × 10−5 |
| 10 | rs2503870 | 43796180 | Intron | HNRNPH3 | DMS-TC | 2.86 × 10−5 |
| 3 | rs6808187 | 175861931 | intergenic | Upstream of LOC730168 | DMS-TC | 2.91 × 10−5 |
| 2 | rs755300 | 241652703 | Intron | KIF1A | DMS-TC | 2.94 × 10−5 |
| 3 | rs4687154 | 190304172 | Intron | IL1RAP | DMS-TC | 2.98 × 10−5 |
| 19 | rs1353166 | 6992943 | intergenic | BRUNOL4 | DMS-TC | 3.02 × 10−5 |
| 1 | rs347272 | 162318498 | Intron | NOS1AP | DMS-TC | 3.04 × 10−5 |
| 1 | rs11577628 | 162319524 | Intron | NOS1AP | DMS-TC | 3.04 × 10−5 |
| 1 | rs347273 | 162317513 | Intron | NOS1AP | DMS-TC | 3.04 × 10−5 |
| 17 | rs8065154 | 17614947 | Intron | RAI1 | DMS-TC | 3.11 × 10−5 |
| 17 | rs6502615 | 17612023 | Intron | TADA2L | DMS-TC | 3.11 × 10−5 |
| 10 | rs12268934 | 13581758 | intergenic | Downstream of RASGEF1A | DMS-TC | 3.21 × 10−5 |
| 17 | rs11263747 | 35742069 | Intron | RAI1 | DMS-TC | 3.30 × 10−5 |
| 17 | rs11263750 | 35816826 | Intron | RAI1 | DMS-TC | 3.30 × 10−5 |
| 17 | rs11868171 | 35816330 | Intron | C17orf78 | DMS-TC | 3.30 × 10−5 |
| 17 | rs2898656 | 35806418 | Intron | ACACA | DMS-TC | 3.30 × 10−5 |
| 20 | rs2024886 | 5700696 | Intron | PTPRT | DMS-TC | 3.31 × 10−5 |
| 11 | rs583983 | 117525125 | Intron | DSCAML1 | DMS-TC | 3.32 × 10−5 |
| 18 | rs72899323 | 39845104 | Intron | LINC00907 | DMS-TC | 3.34 × 10−5 |
| 19 | rs1035525 | 39299362 | Intron | LGALS4 | DMS-TC | 3.50 × 10−5 |
| 12 | rs10846743 | 125310305 | Intron | SCARB1 | DMS-TC | 3.51 × 10−5 |
| 21 | rs7283946 | 42143503 | Intron | DSCAM | DMS-TC | 3.51 × 10−5 |
| 14 | rs10131813 | 23745533 | Intron | HOMEZ | DMS-TC | 3.58 × 10−5 |
| 14 | rs10144278 | 23749595 | Intron | HOMEZ | DMS-TC | 3.58 × 10−5 |
| 15 | rs72633609 | 96389640 | intergenic | Upstream of LOC100132798 | DMS-TC | 3.66 × 10−5 |
| 15 | rs11858405 | 96331346 | Intron | GABRG3 | DMS-TC | 3.66 × 10−5 |
| 2 | rs6544072 | 99112745 | Intron | INPP4A | DMS-TC | 3.68 × 10−5 |
| 8 | rs10111291 | 121266654 | Intron | COL14A1 | DMS-TC | 3.68 × 10−5 |
| 17 | rs58509949 | 35016090 | Intron | TADA2L | DMS-TC | 3.70 × 10−5 |
| 12 | rs7137152 | 66063249 | Intron | SCARB1 | DMS-TC | 3.75 × 10−5 |
| 12 | rs17120580 | 66018826 | intergenic | Upstream of LOC204010 | DMS-TC | 3.75 × 10−5 |
| 10 | rs2349764 | 85675348 | intergenic | At upstream of PRPF18 | DMS-TC | 3.76 × 10−5 |
| 14 | rs8005082 | 28802074 | Intron | HOMEZ | DMS-TC | 3.78 × 10−5 |
| 12 | rs7968661 | 99137384 | Intron | ANKS1B | DMS-TC | 3.81 × 10−5 |
| 13 | rs9315422 | 37055511 | intergenic | Downstream of CCNA1 | DMS-TC | 3.86 × 10−5 |
| 1 | rs4660239 | 43431528 | Intron | SLC2A1-AS1 | DMS-TC | 3.95 × 10−5 |
| 14 | rs1958005 | 33646022 | Intron | HOMEZ | DMS-TC | 3.97 × 10−5 |
| 2 | rs6544072 | 37619430 | intergenic | Downstream of QPCT | DMS-TC | 4.01 × 10−5 |
| 8 | rs7829966 | 53081817 | Intron | ST18 | DMS-TC | 4.01 × 10−5 |
| 7 | rs7794560 | 143029983 | Intron | CLCN1 | DMS-TC | 4.06 × 10−5 |
| 3 | rs17659353 | 3111436 | Intron | IL5RA | DMS-TC | 4.09 × 10−5 |
| 5 | rs10059239 | 18879807 | intergenic | Downstream of LOC646241 | DMS-TC | 4.15 × 10−5 |
| 7 | rs3298 | 154685873 | Intron | DPP6 | DMS-TC | 4.17 × 10−5 |
| 16 | rs9924423 | 64526807 | intergenic | Upstream of CDH5 | DMS-TC | 4.18 × 10−5 |
| 9 | rs12237468 | 125491634 | Intergenic | Downstream of OR1L4 | DMS-TC | 4.19 × 10−5 |
| 5 | rs56196053 | 115759247 | intergenic | Upstream of SEMA6A | DMS-TC | 4.20 × 10−5 |
| 5 | rs1480583 | 105022790 | intergenic | Downstream of RAB9P1 | DMS-TC | 4.25 × 10−5 |
| 14 | rs912857 | 33657980 | Intron | NPAS3 | DMS-TC | 4.85 × 10−5 |
| 1 | rs12024045 | 14297220 | Intron | KAZN | DMS-TC | 4.86 × 10−5 |
CHR: Chromosome; DMS-TC: Delay-matching-to-sample total correct numbers; SNP: Single nucleotide polymorphism.