Table 3.
Meta-analysis results Between IL-10 Polymorphisms and NHL Risk
| Comparisons | B vs. A | BB vs. AA | AB vs. AA | BB vs. AA+AB | AB+BB vs. AA | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| rs1800890 | 1.06 (0.98-1.14) | 0.15 | 1.12 (0.96-1.31) | 0.16 | 1.04 (0.97-1.13) | 0.29 | 1.10 (1.00-1.22) | 0.06 | 1.06 (0.99-1.14) | 0.10 |
| Caucasian | 1.03 (0.97-1.10) | 0.29 | 1.07 (0.94-1.21) | 0.29 | 1.02 (0.93-1.11) | 0.74 | 1.07 (0.95-1.20) | 0.26 | 1.03 (0.95-1.12) | 0.50 |
| B-NHL | 1.09 (1.01-1.19) | 0.03 | 1.18 (0.99-1.41) | 0.06 | 1.08 (1.00-1.18) | 0.06 | 1.15 (1.03-1.28) | 0.01 | 1.11 (1.03-1.20) | 0.008 |
| T-NHL | 0.91 (0.76-1.08) | 0.27 | 0.78 (0.53-1.16) | 0.22 | 0.97 (0.75-1.24) | 0.80 | 0.79 (0.55-1.14) | 0.21 | 0.93 (0.73-1.17) | 0.52 |
| DLBCL | 1.16 (1.08-1.25) | 0.0001 | 1.35 (1.16-1.57) | 0.0001 | 1.15 (1.03-1.28) | 0.02 | 1.25 (1.09-1.44) | 0.001 | 1.20 (1.08-1.33) | 0.001 |
| CLL/SLL | 0.99 (0.90-1.10) | 0.91 | 0.97 (0.79-1.20) | 0.81 | 1.00 (0.86-1.16) | 0.96 | 0.99 (0.82-1.20) | 0.92 | 0.99 (0.86-1.14) | 0.94 |
| FL | 1.07 (0.97-1.18) | 0.19 | 1.14 (0.93-1.40) | 0.19 | 1.04 (0.90-1.21) | 0.57 | 1.12 (0.93-1.35) | 0.22 | 1.07 (0.93-1.23) | 0.34 |
| rs1800896 | 1.14 (1.00-1.29) | 0.02 | 1.26 (0.96-1.64) | 0.09 | 1.20 (1.05-1.37) | 0.007 | 1.12 (0.90-1.40) | 0.313 | 1.22 (1.08-1.39) | 0.002 |
| Caucasian | 1.12 (0.96-1.30) | 0.16 | 1.20 (0.88-1.64) | 0.25 | 1.21 (1.04-1.41) | 0.01 | 1.07 (0.83-1.38) | 0.62 | 1.22 (1.00-1.48) | 0.048 |
| B-NHL | 1.12 (0.98-1.29) | 0.09 | 1.23 (0.93-1.62) | 0.15 | 1.22 (1.06-1.40) | 0.007 | 1.09 (0.86-1.38) | 0.49 | 1.23 (1.08-1.41) | 0.002 |
| DLBCL | 1.15 (0.97-1.36) | 0.11 | 1.32 (0.91-1.91) | 0.14 | 1.26 (1.05-1.52) | 0.01 | 1.14 (0.83-1.56) | 0.41 | 1.29 (1.08-1.53) | 0.004 |
| CLL/SLL | 1.17 (0.70-1.94) | 0.55 | 0.84 (0.53-1.35) | 0.48 | 1.15 (0.80-1.66) | 0.45 | 0.81 (0.54-1.20) | 0.29 | 1.08 (0.76-1.52) | 0.67 |
| FL | 1.14 (0.97-1.34) | 0.12 | 1.27 (0.92-1.76) | 0.15 | 1.07 (0.81-1.41) | 0.64 | 1.25 (0.95-1.63) | 0.11 | 1.14 (0.88-1.47) | 0.33 |
| rs1800871 | 1.05 (0.93-1.18) | 0.43 | 1.24 (0.90-1.70) | 0.19 | 1.22 (0.88-1.69) | 0.23 | 1.03 (0.89-1.19) | 0.69 | 1.24 (0.91-1.69) | 0.18 |
| Caucasian | 1.11 (0.95-1.29) | 0.18 | 1.38 (0.92-2.06) | 0.12 | 1.29 (0.86-1.94) | 0.23 | 1.09 (0.91-1.32) | 0.36 | 1.35 (0.91-2.00) | 0.13 |
| B-NHL | 1.04 (0.91-1.18) | 0.56 | 1.33 (0.94-1.87) | 0.10 | 1.36 (0.96-1.93) | 0.08 | 1.00 (0.85-1.16) | 0.96 | 1.35 (0.96-1.88) | 0.08 |
| DLBCL | 1.03 (0.79-1.35) | 0.80 | 1.43 (0.89-2.30) | 0.14 | 1.52 (0.94-2.47) | 0.08 | 0.97 (0.70-1.34) | 0.84 | 1.48 (0.93-2.36) | 0.10 |
| FL | 0.99 (0.82-1.20) | 0.95 | 1.16 (0.70-1.95) | 0.56 | 1.18 (0.70-1.98) | 0.53 | 0.96 0.76-1.21) | 0.71 | 1.17 (0.71–1.92) | 0.54 |
| rs1800872 | 1.02 (0.93-1.11) | 0.71 | 1.05 (0.85-1.29) | 0.66 | 1.07 (0.86-1.32) | 0.55 | 1.01 0.91-1.13) | 0.85 | 1.06 (0.87-1.29) | 0.59 |
| Caucasian | 1.06 (0.97-1.17) | 0.21 | 1.18 (0.93-1.50) | 0.17 | 1.17 (0.91-1.49) | 0.22 | 1.05 (0.93–1.19) | 0.39 | 1.18 (0.93-1.48) | 0.17 |
| B-NHL | 1.18 (0.99-1.40) | 0.06 | 1.55 (1.00-2.41) | 0.05 | 1.36 (0.87-2.14) | 0.17 | 1.17 (0.95-1.44) | 0.15 | 1.47 (0.96-2.26) | 0.08 |
| DLBCL | 1.28 (1.01-1.62) | 0.04 | 2.06 (1.06-3.99) | 0.03 | 1.77 (0.91-3.48) | 0.10 | 1.26 (0.95-1.68) | 0.11 | 1.95 (1.02-3.72) | 0.04 |
| FL | 1.08 (0.85-1.36) | 0.54 | 1.19 (0.65-2.16) | 0.58 | 1.03 (0.56-1.91) | 0.92 | 1.09 (0.82-1.44) | 0.57 | 1.12 (0.62-2.01) | 0.71 |
A: the major allele; B: the minor allele; CI: confidence interval; OR: odds ratio; B-NHL: B-cell non-Hodgkin’s Lymphoma; T-NHL: T-cell non-Hodgkin’s Lymphoma; DLBCL: diffuse large B-cell Lymphoma; FL: Follicular Lymphoma; CLL/SLL: chronic lymphocytic Leukemia/small lymphocytic Lymphoma.