Table 3.

Single factor Cox proportional hazards regression analysis of parameter changed value in 6 and 12 months groups

Parameter	Group (month)	-2likeihood	HR	95% CI	Wald value	P value
Dyspnea scores	6	47.5	1.012	1.008-1.016	41.656	0.00004**
	12	12.8	1.011	1.004-1.019	8.52	0.004*
FEV1%	6	27.4	0.937	0.911-0.963	21.71	0.00003**
	12	10	0.024	0.001-0.933	3.993	0.046*
FVC%	6	56	0.918	0.895-0.941	45.286	0.00002**
	12	30	0.894	0.852-0.934	20.713	0.00005**
TLC%	6	12	0.974	0.953-0.993	5.81	0.016*
	12	13	0.959	0.933-0.986	8.76	0.003
RV%	6	9	0.993	0.985-1.001	3.028	0.082
	12	6	1.007	0.993-1.022	0.922	0.337
DLCO%	6	29	0.952	0.931-0.970	23.35	0.00001**
	12	26	0.932	0.906-0.959	23.44	0.00001**
PaO2 (mmHg)	6	21	0.928	0.895-0.962	16.25	0.00005**
	12	23	0.919	0.888-0.950	24.07	0.00009**
PaCO2 (mmHg)	6	5	0.997	0.97-1.025	1.806	0.098
	12	3	1.015	0.962-1.139	0.775	0.644
SaO2%	6	22	0.848	0.786-0.915	18.115	0.00002**
	12	17	0.803	0.716-0.901	14.033	0.0002**
PA-aO2 (mmHg)	6	62	1.177	1.12-1.237	41.566	0.00001**
	12	20	1.177	1.088-1.274	16.474	0.00005**

^* P < 0.05, compared with base line value;

^** P < 0.001, compared with base line value.