Table 4.

Single factor Cox proportional hazards regression analysis of parameter changed rate in 6 and 12 months group

Parameter	Group (month)	-2likeihood	HR	95% CI	Wald value	P value
Dyspnea scores	6	72.7	1.441	1.301-1.596	49.161	0.00002**
	12	25.3	1.62	1.30-2.03	18.48	0.00002**
FEV1, %	6	30.6	0.952	0.933-0.971	23.133	0.00002**
	12	13	0.923	0.872-0.977	7.523	0.006*
FVC, %	6	76.6	0.859	0.824-0.895	51.55	0.00007**
	12	40	0.874	0.829-0.913	32.65	0.00001**
TLC, %	6	13	0.978	0.963-0.994	7.665	0.006*
	12	15	0.968	0.948-0.998	9.415	0.002*
RV, %	6	7	0.956	0.945-1.012	2.028	0.182
	12	7	1.017	0.983-1.122	1.922	0.937
DLCO, %	6	38	0.962	0.949-0.976	29.506	0.00006**
	12	35	0.942	0.921-0.962	29.22	0.00007**
PaO2, mmHg	6	30	0.926	0.898-0.956	23.214	0.00001**
	12	27	0.928	0.9-0.956	24.084	0.00009**
PaCO2, mmHg	6	6	0.987	0.96-1.015	0.806	0.369
	12	4	1.021	0.942-1.064	0.175	0.584
SaO2, %	6	24	0.846	0.785-0.911	19.524	0.0001**
	12	19	0.806	0.721-0.9	14.507	0.0001**
PA-aO2, mmHg	6	68	1.054	1.038-1.07	46.944	0.00007**
	12	23	1.055	1.03-1.08	18.629	0.00009**

^* P < 0.05, compared with base line value;

^** P < 0.001, compared with base line value.