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Liver transduction of fiber-mutated Ad5 vectors. A. luciferase expression visualized by whole-body bioluminescence imaging 48 h after systemic administration of Ad5 vectors with 1 × 109 PFU/mouse. B. viral genome content in the liver of mice 48 h after injection with Ad5 vectors. Ad genomes were detected in the liver after DNA extraction and analysis by quantitative PCR (*P < 0.05 vs. Ad5-Luc, n = 5).
