Table 1.
Characteristics of included studies
| First author | Year | Country | Malignant disease | Histological type | Stage (I II/III IV) | Sample size (male) | Follow-up median (months) | Outcome indexes | Design of Data Collection | Detection method | Staining pattern | Cut-off value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Luo et al. | 2013 | China | Nasopharyngeal carcinoma | SCC | 33/89 | 122 (92) | 60.1 (8-92) | OS | Retrospective | IHC | nucleus | Score ≥ 6 (0-9) |
| Wang et al. | 2012 | China | Nasopharyngeal carcinoma | SCC | 40/68 | 108 (76) | 86.4 | OS | Retrospective | IHC | nucleus | Score ≥ 9 (0-12) |
| Ge et al. | 2010 | China | Hypopharyngeal carcinoma | SCC | 7/78 | 85 (84) | 52 (7-69.5) | OS/DFS | Retrospective | IHC | nucleus | Score ≥ 4 (0-7) |
| Dai et al. | 2014 | China | Salivary gland adenoid cystic | ACC | NA | 131 (75) | 38.6 (3-62) | OS/DFS | Retrospective | IHC | nucleus | Score ≥ 6 (0-9) |
| Du et al. | 2013 | China | Oral tongue carcinoma | SCC | NA | 82 (55) | 67 (4-81) | OS/DFS | Retrospective | IHC | nucleus | Score ≥ 2 (0-7) |
| Tang et al. | 2011 | China | Laryngeal carcinoma | SCC | 65/96 | 161 (152) | 46.3 (8-60) | OS | Retrospective | IHC | nucleus | Score ≥ 6 (0-7) |
| Márquez et al. | 2013 | Spain | Hypopharyngeal carcinoma | SCC | 7/95 | 102 (99) | 14 (0-95) | OS/DFS | Retrospective | IHC | nucleus | > 5% |
| 2013 | Spain | Laryngeal carcinoma | SCC | 13/54 | 67 (67) | 37 (1-97) | OS/DFS | Retrospective | IHC | nucleus | > 5% | |
| 2013 | Spain | Sinonasal carcinoma | SCC | 4/47 | 51 (37) | 18 (1-211) | OS/DFS | Retrospective | IHC | nucleus | > 5% |
Abbreviations: OS, overall survival; DFS, disease-free survival; IHC, Immunohistochemistry; SCC, squamous cell carcinoma; ACC, adenoid cystic carcinomas.