Table 3.

Cox univariate and multivariate analysis in progression-free survival and overall survival

Variables	Progression-free survival			Overall survival
	Univariate		Multivariate	Univariate		Multivariate
	P	HR	P	P	HR	P
Age (< 58/≥ 58)	0.742	0.881	NA	0.710	1.177	NA
Sex (female/male)	0.122	0.549	NA	0.059	0.426	NA
TNM stage (II/III-IV)	0.890	1.033	0.850	0.611	1.148	0.466
Tumor types (CC/GB)	0.463	1.328	0.599	0.240	1.673	0.868
Chemotherapy method	0.547	0.946	0.927	0.120	0.669	0.114
RRM1 (N/P)	0.507	0.767	0.718	0.945	0.968	0.173
hENT-1 (N/P)	0.005	0.330	0.005	0.048	0.413	0.143

CC, Cholangiocarcinoma; GB, Gallbladder; N, negative; P, Positive; HR, Hazard ratio.