Table 1.
Characteristics of the studying population
| Parameters | ARDS patients | Ventilated controls | Healthy controls | P-value (ARDS versus ventilated controls) |
|---|---|---|---|---|
| Number of subjects | 22 | 14 | 12 | |
| Age (years, mean ± SD) | 61 ± 13 | 59 ± 15 | 59 ± 16 | p=0.67 |
| Female sex (n, %) | 9 (41%) | 6 (43%) | 6 (50%) | p=0.91 |
| Cause of ARDS (n, %) | ||||
| Pneumonia | 16 | |||
| Aspiration | 3 | |||
| Lung contusion | 1 | |||
| Extra pulmonary sepsis | 2 | |||
| SOFA score | 6 ± 3 | 7 ± 3 | p=0.34 | |
| PaO2:FiO2 ratio (kPa) | 16.2 ± 3.3 | 32.8 ± 3.5 | p < 0.01 | |
| PaCO2 (kPa) | 8.1 ± 1.0 | 5.9 ± 1.1 | p < 0.01 | |
| Tidal volume (mL/kg predicted weight) | 9.1 ± 2.2 | 9.5 ± 2 | p=0.58 | |
| PEEP (cmH2O) | 9.4 ± 2.0 | 6.2 ± 1.4 | p < 0.01 | |
| sRAGE levels (pg/ml, mean ± SEM) | 1797 ± 383 | 650 ± 192 | 415 ± 178 | p < 0.01 |
ARDS, acute respiratory distress syndrome; SOFA, Sequential Organ Failure Assessment; PaO2, arterial oxygen tension; FiO2, inspiratory oxygen fraction; PaCO2, arterial carbon dioxide tension; PEEP, positive end-expiratory pressure; sRAGE, soluble receptor for advanced glycation end products; SD, standard deviation; SEM, standard error of the mean.