Table 4.
Effects of essential oil on PGE2, histamine and 5-HT in the exudates of rat edema paw induced by carrageenan
| Groups | Dose | PGE2 (μg/g) (inhibition %) | Histamine (FV) (inhibition %) | 5-HT (FV) (inhibition %) |
|---|---|---|---|---|
| Solvent control | 0.2 (ml/10 g) | 435.23 ± 24.94 | 29.24 ± 3.97 | 25.31 ± 0.99 |
| Indomethacin | 2 (mg/kg) | 228.63 ± 15.58 (47.47)** | 21.24 ± 2.87 (27.36)** | 24.06 ± 0.77 (4.94)* |
| Group III | 0.5 (ml/kg) | 251.26 ± 13.41 (42.27)** | 22.81 ± 2.01 (21.99)* | 23.90 ± 0.31 (5.57)* |
| Group II | 0.25 (ml/kg) | 284.94 ± 17.94 (34.53)** | 24.34 ± 4.67 (16.76)* | 24.96 ± 0.39 (1.38)* |
| Group I | 0.13 (ml/kg) | 320.25 ± 16.83 (26.42)** | 24.98 ± 3.07 (14.57)* | 25.28 ± 0.69 (0.12) |
Values are mean ± SEM (n=8).
*
p < 0.05 significant from solvent control group;
**
p < 0.01 significant from solvent control group.