Table 4.
The clinical data of vaginal intraepithelial neoplasia (VAIN) patients
| CIN III | CSCC II a2 | CSCC I a2# | CSCC II a1 | CSCC II a1 | CSCC I b1 | |
|---|---|---|---|---|---|---|
| Operation time | Aug. 2009 | Jan. 2009 | Jan. 2009 | Feb. 2009 | Mar. 2010 | May. 2010 |
| Preoperative high-risk HPV | 374.96 | 807.36 | 1084.62 | 380.25 | 1430.04 | 951.07 |
| VAIN diagnosis time | VAIN II in Mar. 2012 | VAIN I in Nov. 2010 | VAIN III in Oct. 2011 VAIN III recurrence in Jun. 2012 | VAIN III in Jun. 2011 | VAIN III in Feb. 2011 | VAIN III in Apr. 2013 |
| High-risk HPV value in VAIN | 0.87 | 1530.83 | 1520.92 1154.61 during 2nd surgery | 53.46 | 5.38 | 947.24 |
| Continuous infection time by high-risk HPV | - | 5 months | 42 months | 18 months | -## | 35 months |
| Therapies | Laser therapy | Interferon therapy | Resection by 2 surgeries | Resection by surgery | Resection by surgery | Resection by surgery |
| Patient outcomes after follow-up | TCT (-) HPV 0.26 | HPV 0.33 and TCT (-) in Apr. 2011; Died of intestinal obstruction in Jun. 2012 | TCT (-) HPV 5.33 | TCT (-) HPV 1.35 | TCT (-) HPV 0.51 | TCT (-) HPV 54.3 |
Note: CIN, cervical intraepithelial neoplasia; CSCC, cervical squamous cell carcinoma.
this patient had sustained infection by high-risk HPV before and after surgery. In month 22 after the surgery, 2 × 2.5 erosion surface was found on the left side of vaginal cuff. TCT result indicated squamous cell carcinoma and colposcopy confirmed VAIN III. After surgical resection, TCT result was negative, but the patient still had infection by high-risk HPV. Seven months later, VAIN III was diagnosed again before surgical treatment was carried out.
This patient had a semi-quantitative HPV-DNA value of 0.25 and negative TCT result 3 months after the surgery. Eleven months after the surgery, high-risk HPV-DNA was 5.38, TCT result was HSIL, and VAIN III was diagnosed by colposcopy. Time of sustained infection by high-risk HPV was unclear.