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. 2015 Jan 19;9:603–624. doi: 10.2147/DDDT.S62912

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© 2015 Pehrson and Sanchez. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Amino acid neurotransmitter synthesis and catabolism. The synthesis and catabolism of GABA and glutamate are tightly interconnected in the brain.

Abbreviations: αKGDH, α-ketoglutarate dehydrogenase; AAT, aspartate aminotransferase; CoA, coenzyme A; Cys, cysteine; GABA, γ-aminobutyric acid; GDH, glutamate dehydrogenase; GABA-T, GABA transaminase; GAD, glutamic acid dehydrogenase; GCL, γ-glutamyl cysteine ligase; Gln, glutamine; Glu, glutamyl; Gly, glycine; GSH, glutathione; GHB, γ-hydroxybutyric acid; GGT, γ-glutamyl transferase; GGCT, γ-glutamyl cyclotransferase; OPLAH, 5-oxoprolinase (adenosine triphosphate-hydrolyzing); SSADH, succinic semialdehyde dehydrogenase; SSAR, succinic semialdehyde reductase.