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. 2014 Dec;27(2):252–267. doi: 10.1017/S0954422414000183

Fig. 2.

Fig. 2

Diagram of the relationship between bone resorption or formation and bone turnover markers. On the resorption side, tartrate-resistant acid phosphatase (TRAP) reflects osteoclast number and activity, whereas pyridium cross-links, carboxy terminal telopeptide (CTX) and N-terminal telopeptide (NTX) are markers of bone matrix resorption. On the formation side, collagen type I propeptides, such as procollagen type I N-terminal propeptide (PINP), bone alkaline phosphatase (BAP) and osteocalcin reflect mainly osteoblastic bone formation. Osteoid corresponds to the non-mineralised bone matrix.