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. 2014 Dec;27(2):252–267. doi: 10.1017/S0954422414000183

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© The Authors 2014

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Diagram of the relationship between bone resorption or formation and bone turnover markers. On the resorption side, tartrate-resistant acid phosphatase (TRAP) reflects osteoclast number and activity, whereas pyridium cross-links, carboxy terminal telopeptide (CTX) and N-terminal telopeptide (NTX) are markers of bone matrix resorption. On the formation side, collagen type I propeptides, such as procollagen type I N-terminal propeptide (PINP), bone alkaline phosphatase (BAP) and osteocalcin reflect mainly osteoblastic bone formation. Osteoid corresponds to the non-mineralised bone matrix.