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Optogenetics schemes using ChR2 in the retinitis pigmentosa retina after loss of layer 1 photoreceptors. (a) Targeting either ON bipolar cells or AII amacrine cells with ChR2 (color) can potentially drive all ganglion cell classes with correct polarities and waveforms. (b) Targeting ganglion cells generates the same waveform in all ganglion cell classes, which may compromise useful vision.
